Photodynamic therapy (PDT) is a clinical treatment that uses a combination of light, photosensitising drugs and molecular oxygen to kill diseased cells. Upon absorption of light energy by the sensitizer, an electron is promoted from the singlet ground state (S0) to a higher energy singlet excited state (S1, S2…). Any electrons that occupy orbitals higher than S1 return to S1 via a non-radiative process known as internalRead More
Sonodynamic therapy (SDT) is an emerging therapeutic approach that offers very significant potential in the treatment of cancer. The term ‘sonodynamic’ first appeared in the scientific literature in the late 1980s when a Japanese research group discovered that treating porphyrins (naturally-occurring molecules – e.g. the organic part of the haem group in haemoglobin) with ultrasound, resulted in the generationRead More
Antimicrobial PDT /SDT
Currently, drugs used to combat infection are on the verge of being beaten by the bacteria they are designed to kill. Bacteria are constantly adapting to enable them to resist treatment by antibiotics-so called “resistant strains of bacteria”. Probably the best example of such a bacterium is Methicillin Resistant Staphylococcus Aureus (MRSA). Now the drug used to treat MRSA, vancomycin, is also showing evidence of resistance.Read More
Drug molecules with molecular weights in excess of 1kDa are usually taken by cells through the process of endocytosis which can prevent them from reaching their intracellular target due to entrapment and enzymatic degradation within endocytic vesicles. PCI is an emerging technique that can be used to rupture the endosome releasing the drug(s) captured within. In PCI, a low concentration of an amphiphilc sensitiser is co-administered with the drug and localises in the membrane of the drug encapsulated endosome.Read More
Prof Callan delivers lecture on work conducted by CPSR researchers entitled “Shining light on Cancer-new perspectives in Photodynamic Therapy” to the Institute of Biomedical Engineering at the University of Oxford.
Congratulations to CPSR researchers Conor McEwan, Dr Sukanta Kamila and Dr Heather Nesbitt who published their research in the leading drug delivery journal Biomaterials. The article entitled “Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle” (Biomaterials 2016, 80, 20-32) is a collaboration between CPSR researchers and researchers from the University of Oxford, UCL and the Colorado.
Congratulations to CPSR researcher Jordan Atchison for publishing his work entitled “Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser” in Chemical Communications. Congratulations also to CPSR co-authors , Dr Sukanta Kamila, Dr Heather Nesbitt and Conor McEwan. (Full details: Jordan Atchison, Sukanta Kamila, Conor McEwan, Heather Nesbitt, James Davis, Colin Fowley, Bridgeen Callan, Anthony P. McHale and John F. Callan. Chem Commun., 2015, DOI: 10.1039/C5CC07022H).