Photodynamic therapy (PDT) is a clinical treatment that uses a combination of light, photosensitising drugs and molecular oxygen to kill diseased cells. Upon absorption of light energy by the sensitizer, an electron is promoted from the singlet ground state (S0) to a higher energy singlet excited state (S1, S2…). Any electrons that occupy orbitals higher than S1 return to S1 via a non-radiative process known as internal

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Sonodynamic therapy (SDT) is an emerging therapeutic approach that offers very significant potential in the treatment of cancer. The term ‘sonodynamic’ first appeared in the scientific literature in the late 1980s when a Japanese research group discovered that treating porphyrins (naturally-occurring molecules – e.g. the organic part of the haem group in haemoglobin) with ultrasound, resulted in the generation

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Antimicrobial PDT /SDT

Currently, drugs used to combat infection are on the verge of being beaten by the bacteria they are designed to kill. Bacteria are constantly adapting to enable them to resist treatment by antibiotics-so called “resistant strains of bacteria”. Probably the best example of such a bacterium is Methicillin Resistant Staphylococcus Aureus (MRSA). Now the drug used to treat MRSA, vancomycin, is also showing evidence of resistance.

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Drug molecules with molecular weights in excess of 1kDa are usually taken by cells through the process of endocytosis which can prevent them from reaching their intracellular target due to entrapment and enzymatic degradation within endocytic vesicles. PCI is an emerging technique that can be used to rupture the endosome releasing the drug(s) captured within. In PCI, a low concentration of an amphiphilc sensitiser is co-administered with the drug and localises in the membrane of the drug encapsulated endosome.

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Latest News


bullet_square_glass_blueProf Callan delivers lecture on work conducted by CPSR researchers entitled “Shining light on Cancer-new perspectives in Photodynamic Therapy” to the Institute of Biomedical Engineering at the University of Oxford.

bullet_square_glass_blueCPSR research into pancreatic cancer has been highlighted on BBC news and national media. Click here to read more from the BBC News article and video.

bullet_square_glass_blueCongratulations to CPSR researchers Conor McEwan, Dr Sukanta Kamila and Dr Heather Nesbitt who published their research in the leading drug delivery journal Biomaterials. The article entitled “Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle” (Biomaterials 2016, 80, 20-32) is a collaboration between CPSR researchers and researchers from the University of Oxford, UCL and the Colorado.

bullet_square_glass_blueCPSR welcomes Dr Heather Nesbitt as a Research Associate in Tumour Biology.

bullet_square_glass_blueCongratulations to CPSR researcher Jordan Atchison for publishing his work entitled “Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser” in Chemical Communications. Congratulations also to CPSR co-authors , Dr Sukanta Kamila, Dr Heather Nesbitt and Conor McEwan. (Full details: Jordan Atchison, Sukanta Kamila, Conor McEwan, Heather Nesbitt, James Davis, Colin Fowley, Bridgeen Callan, Anthony P. McHale and John F. Callan. Chem Commun., 2015, DOI: 10.1039/C5CC07022H).

bullet_square_glass_blue Congratulations to CPSR student Jason Sheng on succesfully completing his PhD transfer talk entitled ‘Enhancing the efficacy of PDT in Hypoxic Tumours’.